Publication details.

Paper

Year:2019
Author(s):J. Cartwright, O. Piro, I. Tuval
Title:Chemosensing versus mechanosensing in nodal and Kupffer’s vesicle cilia
Journal:PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
ISSN:0962-8436
Volume:375
Pages:20190566
D.O.I.:https://doi.org/10.1098/rstb.2019.0566
Web:https://royalsocietypublishing.org/doi/10.1098/rstb.2019.0566
Abstract:How is sensing carried out by cilia in the mouse node, zebrafish Kupffer’s vesicle, and similar organizer organs in other species? Two possibilities have been put forward. In the former, cilia would detect the presence of some chemical species in the fluid; in the latter, they would detect fluid flow. In either case, the hypothesis is that an imbalance would be detected between this signalling coming from cilia on the left and right sides of the organizer, which would initiate a cascade of signals leading ultimately to the breaking of left-right symmetry in the body plan of the organism. We review the evidence for both hypotheses.

Related staff

  • Idan Tuval Gefen
  • Oreste Piro
  • Related departments

  • Marine Ecology
  • Related projects

  • INTERDIBIO
  • Related research groups

  • Marine Ecosystems Dynamics