Publication details.

Paper

Year:2020
Author(s):S. Vallejo-Diez, A. Fleischer, J. María Martín-Fernández, A. Sánchez-Gilabert, C. Gómez-Martínez, M. Castresana, D. Bachiller
Title:Generation of one iPSC line (IMEDEAi007-A) by Sendai Virus transduction of PBMCs from a Psoriasis donor
Journal:Stem Cell Research
ISSN:1873-5061
JCR Impact Factor:2.02
Volume:47
Pages:101917
D.O.I.:10.1016/j.scr.2020.101917
Web:https://dx.doi.org/10.1016/j.scr.2020.101917
Abstract:© 2020Psoriasis is a chronic inflammatory skin disease that speeds up the life cycle of skin cells, forming scales and red patches that are itchy and sometimes painful. It is a complex disease of autoimmune origin and genetic predisposition with more than 10 different loci associated. Here we described the production of an iPSC line generated by Sendai Virus (Klf4, Oct3/4, Sox2 and c-Myc) reprogramming of Peripheral Blood Mononuclear Cells (PBMCs) from a Psoriasis patient. The iPSC line generated has normal 46XY karyotype, is free of SeV genome and transgenes insertions, express high levels of pluripotency markers and can differentiate into all three germ layers.

Related staff

  • Carmelo Gómez Martínez
  • Related departments

  • CSIC staff non-ascribed